Priligy is a medicine that normalizes sexual function in men which has dapoxetine as the main ingredient. The effect of dapoxetine in premature ejaculation is associated with its ability to inhibit the reuptake of serotonin by nerve structures, with the subsequent potentiation of neurotransmitter effects on postsynaptic and presynaptic receptors. This medication is sold mostly in local pharmacies. But if you want to save some money, then you can buy Priligy online. At the same time, its price will be much lower, and for the convenience of customers, it is possible to order an operative delivery of the medicine directly under the door.
Indications for use
Priligy is used in the therapy of men of reproductive age who suffer from premature ejaculation.
Mode of application
Priligy is used in the form of tablets. The active substance is recommended to be prescribed only to men aged 18-64, patients should be reminded that dapoxetine is not intended for daily use and should be used only when necessary.
The average dose of dapoxetine for a single dose is 30 mg (the active substance should be taken 1-3 hours before the proposed sexual intercourse), if necessary, the dose can be increased to 60 mg, but it is forbidden to start taking Priligy from high doses.
It should be borne in mind that the likelihood of side effects when taking 60 mg of Priligy is increased.
The most frequent side effects in the clinical trials of the drug were dizziness, nausea, insomnia, headache, and weakness. In the course of the study, 2.2% of patients required the abolition of dapoxetine due to the development of severe nausea and 1.2% of patients due to dizziness.
Also during the administration of Priligy, the following undesirable symptoms were recorded in patients:
- CNS: agitation, anxiety, unusual dreams, unreasonable anxiety, decreased libido, depressive states, euphoria, apathy, confusion, pathological thinking, disorientation, sleep disturbances, insomnia, nightmares, bruxism, anorgasmia, headache, paresthesia, dizziness, drowsiness, tremor, impaired concentration, change in taste, fainting, postural dizziness, sedation, lethargy, hypersomnia, sudden falling asleep.
- Organs of senses: mydriasis, decreased visual acuity, pain in the eyes, vertigo, ringing in the ears.
- Сardiovascular system: hot flashes, tachycardia, sinus bradycardia, hypotension, systolic hypertension.
- Respiratory system: yawning, nasal congestion.
- Gastrointestinal tract: dyspepsia, nausea, epigastric pain, dry mouth.
- Skin and subcutaneous tissues: itching, hyperhidrosis, cold sweat.
- Reproductive system: anorgasmia, erectile dysfunction, paresthesia of the genitals, the absence of ejaculation.
- Other: weakness, asthenia, a feeling of heat, a feeling of intoxication.
With the abrupt stoppage of the treatment with drugs that inhibit the reuptake of serotonin, withdrawal can occur, including dizziness, agitation, dysphoric status, sensory disturbances, anxiety, headache, and confusion.
Priligy is contraindicated in hypersensitivity.
Priligy is not used in the treatment of patients with severe cardiovascular pathologies, including heart failure, atrioventricular blockade of 2-3 degrees, sinus node weakness syndrome (without an established pacemaker), ischemic heart disease, and valve apparatus damage.
Priligy is contraindicated in patients receiving monoamine oxidase inhibitors or thioridazine (including 14 days from the withdrawal of these drugs), as well as serotonin reuptake blockers, tricyclic antidepressants, St. John’s Wort preparations, tramadol, lithium preparations and linezolid.
Priligy is not used in the treatment of patients with impaired liver function (including cases of moderate and severe liver damage) and kidney failure.
Priligy is strictly prohibited from use in patients under the age of 18 years.
Priligy is contraindicated in patients who have a history of orthostatic hypotension, bipolar disorder, mania/hypomania.
Relative contraindications to the use the drug are mild violations of kidney activity, intake of moderate inhibitors of liver isoenzymes, as well as drugs that affect platelet aggregation and clotting (due to the risk of bleeding).
Priligy is used only for the treatment of men. Well-controlled studies on the effect of the drug on fertility and the course of pregnancy have not been conducted.
Priligy can be used only in men who have premature ejaculation, there are no data on the safety of the active substance in men without premature ejaculation.
Interaction with other active substances
Priligy is not prescribed concomitantly with narcotic drugs.
Medicinal substances with serotonergic activity, when combined with Priligy, can provoke the development of potentially severe reactions, including serotonin syndrome.
There is an increase in drowsiness and dizziness in a combination of Priligy with benzodiazepines and opiates.
Priligy potentiates the effects of ethyl alcohol, taking alcohol with Priligy is prohibited.
Cases of an overdose in clinical trials are not described. After a single dose of the drug of 240 mg, no serious side effects were reported